Scientists closer to making exercise in a pill 

Scientists have in a breakthrough research identified a protein that acts as an “exercise sensor” which is able to detect changes in the blood flow during exercise, a findings that will mimic the positive health benefits of exercise without actually requiring to break a sweat.

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According to Study:

• The study found that when the heart pumps more blood in the body during physical activity.
• In addition,the Piezo1 protein in the endothelium or lining of the arteries senses the increased pressure on the wall of the blood vessels.
• In response, it slightly alters the electrical balance in the endothelium and this results in the blood vessels constricting.
• This narrowing of the blood vessels reduces blood flow to the stomach and intestines.
• Furthermore,allowing more blood to reach the brain and muscles actively engaged in exercise.

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According to Researchers:

• If we can understand how these systems work.
• Then we may be able to develop techniques that can help tackle some of the biggest diseases afflicting modern societies.
• We know that exercise can protect against heart disease, stroke and many other conditions.
• This study has identified a physiological system that senses when the mammalian body is exercising.
• Furthermore, the researchers investigated the effect of an experimental compound called Yoda1 on the action of the Piezo1 protein.
• They found that it mimicked the action of increasing blood flow on the walls of the endothelium which is experienced during physical activity.
• In addition,raising the possibility that a drug could be developed which enhances the health benefits of exercise.

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By modifying Piezo1 protein in the intestines can help move a step closer to having a drug that can help control cardiometabolic syndrome such as cardiovascular disease and Type 2 diabetes, the researchers said.