Study: Skinny legs may up death risk by 300% 

If you have a lean body shape with normal body mass index but with skinny lower legs, you may be at three-fold increased risk of dying from cardiometabolic diseases such as Type 2 diabetes or cardiovascular disease, a research has claimed.

According to a Study:

• According to the study, lean people who are metabolically unhealthy.
• But have normal weight, might be at a 300 per cent greater chance of dying.
• Norbert Stefan, Professor at the University of Tubingen in Germany.
• Said,this is in contrast to the small proportion of obese people who despite their high body mass index (BMI) are metabolically healthy.
• And for this group, the risk of death from all-cause mortality is only 25 per cent higher than that of healthy lean people, Stefan added.

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Results showed:

• The results showed that among lean people.
• In addition, skinny lower legs may prove to be the strongest predictor of poor metabolic health.
• While for obese people, abdominal fat levels and non-alcoholic fatty liver disease are strong predictors of cardiometabolic diseases such as Type 2 diabetes or cardiovascular disease.
• In lean people, a gene-derived problem of storing fat in the lower limbs may be a crucial factor, placing them at an increased risk of cardiometabolic diseases, Stefan said.
• For the study, detailed in the journal Cell Metabolism, the team analysed data from 981 subjects.

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• After having defined metabolic health as having less than two risk parameters of the metabolic syndrome, they found that 18 per cent of their lean subjects were metabolically unhealthy.
• Using magnetic resonance imaging and magnetic resonance spectroscopy, they determined body fat mass, fat distribution and deposition of fat in the liver.
• Further, they also determined insulin sensitivity, insulin secretion, thickness of the carotid vessel wall and fitness.
• Such unhealthy lean but normal BMI phenotype body-shape also resembled people with certain rare diseases such as lipodystrophy in which the body is unable to sustain adequate fat reserves.
• The findings provide evidence for the existence of a “lipodystrophy-like phenotype in the general population”, the researchers noted.